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    • Publications and Patents
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      • Patents
      • Presentations
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  • Publications and Patents
    • Publications
    • Patents
    • Presentations
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Patents

Issued patents

  1.  “Therapeutically active  compounds and their methods of use.” Popovici-Muller, J.;  Lemieux, R. M.; Travins, J.M.; Cai, Z.; Cui, D.; Zhou, D. US 11667673 B2 (US 10640534 B2, US 10717764 B2, US 9474779 B2, US 9850277 B2).
  2. “Therapeutically active  compounds and their methods of use.” Konteatis, Z.D.; Popovici-Muller,  J.; Travins, J.; Zahler. R.; Cai, Z.; Zhou, D. US 10946023 B2 (US 9579324 B2, US 10172864 B2, US 10028961 B2).
  3. “Heterobicyclic compounds as inhibitors of MAT2A and methods of use for treating cancer.” Konteatis, Z. D.; Li, M.; Liu, P.; Medeiros, M.; Reznik, S. K.; Sui, Z.; Travins, J.  M.; Popovici-Muller, J.; Zhou, S.; Ma, G. US 11524960 B2.
  4. “Therapeutically active compounds and their methods of use.” Lemieux, R. M.; Popovici-Muller, J.; Travins, J.M.; Cai, Z.; Cui, D.; Zhou,  D. US 11021515 B2 (US 10689414 B2).
  5. “Therapeutically active compounds and their methods of use.” Konteatis, Z, D.; Popovici-Muller, J.; Cai, Z.; Zhou, D. US 10946023 B2 (US 10172864 B2, US 10028961 B2).
  6. “2,4- or 4,6-diaminopyrimidine compounds as  IDH2 mutants inhibitors for the treatment of cancer.” Konteatis, Z.D.; Popovici-Muller,  J.; Travins, J. US 10376510  B2.
  7. “Preparation of N-(piperidinecarbonylphenyl) sulfonamide compounds as pyruvate kinase modulators.” Popovici-Muller, J.; Zahler, R.; Ye, Z. US 9365545 B2 (US 9108921 B2).
  8. “Glutaminase inhibitors and method of use.”  Lemieux, R. M.; Popovici-Muller, J.; Salituro, F. G.; Saunders, J. O.; Travins, J.; Yan, S. US 10414740 B2 (US 10011574 B2, US 9303002 B2).
  9. “Compounds and their  methods of use.” Lemieux, R. M.; Popovici-Muller,      J.; Salituro, F. G.; Saunders, J. O.; Travins, J.; Chen, Y. US  10689375 B2 (US 9029531 B2, US 10087172 B2).
  10. “Therapeutic compounds and compositions and their use as PKM2 modulators.” Popovici-Muller, J; Saunders, J. O.; Zahler, R.; Cianchetta,  G. US 9458132 B2.
  11. “Therapeutic compounds and  compositions.” Popovici-Muller, J.; Salituro, F. G.; Saunders, J. O.; Travins, J.; Yan, S. US 10202339 B2.
  12. “Therapeutically active  compounds and their methods of use.” Cianchetta, G.; DeLaBarre, B.; Popovici-Muller,  J; Salituro, F. G.; Saunders, J. O.; Travins, J.; Yan, S.; Guo, T.; Zhang, L. US 11505538 B1 (US 9732062 B2, US 10294215 B2, US  9512107 B2, US 9656999 B2).
  13. “Therapeutically active  compositions and their methods of use.“ Cao, S.; Popovici-Muller, J; Salituro, F. G.; Saunders, J.; Tan, X.; Travins, J.; Yan, S.; Ye, Z. US 9856279 B2 (US 8398828 B1, US 8568573 B2, US 8658035 B2, US 8658046 B2, US 8663471 B1, US 9045357 B2, US 9096450 B2, US 9856279 B2).
  14. “Phenyl and pyridinyl substituted piperidines and piperazines as      inhibitors of IDH1 mutants and their use in treating cancer. “Cao, S.; Popovici-Muller, J;   Salituro, F. G.; Saunders, J.; Tan, X.; Travins, J.; Yan, S.; Ye, Z. US  9662327 B2. 
  15. “Modulators of cell cycle  checkpoints and their use in combination with checkpoint kinase   inhibitors. “Popovici-Muller, J.;  Rosner, K. E.; Guzi, T. J. US  8993535 B2.
  16. “Compounds for the treatment of inflammatory disorders.” Kozlowski, J.A.; Yu, W.; Wong, M. K.      C.; Kim, S-H.; Tong, L.; Lavey, B. J.; Shankar, B.B.; Yang, D-Y.; Feltz,      R.; Kosinski, A. M.; Zhou, G.; Rizvi, R.K.; Dai, C.; Fire, L.; Girijavallabhan, V.M.; Li, D.; Popovici-Muller,  J.; Richard, J. E.; Rosner, K. E.; Siddiqui, M. A.; Yang, L. US 8541572  B2.
  17. “Compounds for the  treatment of inflammatory disorders.“ Tong, L.; Lavey, B. J.; Shankar, B.      B.; Kim, S-H.; Yu, W.; Kozlowski, J.A.; Wong, M.K.C.; Chen, L.; Zhou, G.;      Rizvi, R. K.; Feltz, R.; Kosinski, A. M.; Yang, D-Y.; Dai, C.; Fire, L.;  Girijavallabhan, V. M.; Li, D.; Popovici-Muller, J.; Richard, J.E.; Rosner, K. E.; Siddiqui, M. A.; Yang, L. US 8569336 B2.
  18. “Novel modulators of cell cycle checkpoints and their use in combination with checkpoint kinase  inhibitors.” Guzi, T. J.; Parry, D. A.; Labroli, M. A.; Dwyer, M. P.; Paruch, K.; Rosner, K. E; Shen, R.; Popovici-Muller,  J. US 8603998 B2.
  19. “High affinity quinoline-based kinase ligands.“ Deng, Y.; Curran, P. J.; Shipps, G. W.,  Jr.; Zhao, L.; Siddiqui, M. A.; Popovici-Muller,  J.; Duca, J. S.; Hruza, A. W.; Fischmann, T. O.; Madison, V. S.;  Zhang, R.; McNemar, C. W.; Mayhood, T. W.; Windsor, W. T.; Lees, E. M.;  Parry, D. A. US 7511063 B2.
  20. “Compounds for the treatment of inflammatory disorders”. Lavey, B. J.; Kozlowski, J. A.; Zhou, G.;  Tong, L.; Yu, W.; Wong, M. K. C.; Shankar, B. B.; Shih, N-Y.; Siddiqui, M. A.; Rosner, K. E.; Dai, C.; Popovici-Muller,  J.; Girijavallabhan, V. M.; Li, D.; Rizvi, R.; Chen, L.; Yang, D-Y.;  Feltz, R.; Kim, S-H. US 8178553 B2 (US 7524842 B2, US 7772263 B2, US 7683088 B2).
  21. “Compounds for the treatment of inflammatory disorders.” Yu, W. ; Tong, L.O.; Chen, L.; Kozlowski, J. A.; Lavey, B. J.; Shih, N-Y. Madison, V. S.; Zhou, G. Orth, P. Guo, Z.; Wong, M. K. C.; Yang, D-Y.; Kim, S-H.; Shankar, B.      B.; Siddiqui, M. A.; Rosner, K. E.; Dai, C.; Popovici-Muller, J.; Girijavallabhan, V. M.; Li, D.; Rizvi, R.; Micula, A. M.; Feltz, R. US  7879890 B2 (US 7488745 B2, US 7687527 B2, US 7683085  B2, US 7504424 B2, US 7482370 B2).
  22. “Compounds  for the treatment of inflammatory disorders.”  Guo, Z.; Orth, P.; Zhu, Z.; Mazzola, R. D.; Chan, T-Y.; Vaccaro, H. A.; McKittrick, B.; Kozlowski, J. A.; Lavey, B. J.; Zhou, G.; Paliwal, S.; Wong, S-C; Shih, N-Y; Ting, P. .; Rosner, K. E.; Shipps, G. W. Jr.; Siddiqui, M. A.; Belanger, D. B.;      Dai, C.; Li, D.; Girijavallabhan, V. M.; Popovici-Muller, J.; Yu, W.; Zhao, L. US 7638513 B2 (US      7652020 B2, US 8039467 B2).
  23. “Pyrazolo[1,5-a]pyrimidine compounds as antiviral agents against hepatitis C virus (HCV) infection.” Shipps, G. W.; Rosner  K. E.; Popovici-Muller, J.; Deng, Y.; Wang, T.; Curran, P. J. US 7449488 B2 (US 7196111 B2).

Patent applications

  1.  “Pyridine carboxamide  compounds and their use in treating medical conditions”. Bosanac, T;      Fuller N.O.; Hughes, R. O; Bemis, G.; Popovici-Muller,  J. V. WO 2024/072794. 
  2. “Pyridine carboxamide compounds and their use in treating medical conditions”. Bosanac, T;      Fuller N.O.; Hughes, R. O; Bemis, G.; Popovici-Muller,  J. V. WO 2024/072793. 
  3. “Therapeutically active compositions and their methods of use.“ Popovici-Muller, J; Salituro, F. G.; Saunders, J. O.; Travins, J.; Yan, S. WO 2012/009678.
  4. “Therapeutically active compounds and their methods of use”. Popovici-Muller, J; Salituro, F. G.;  Saunders, J. O.; Salituro, F. G.; Cai, Z.; Zhou, D.; Yan, S. WO 2013/107405.
  5. “Novel high affinity quinoline-based kinase ligands and their preparation, pharmaceutical compositions and use in the treatment and prevention of diseases.“ Deng, Y.; Curran, P. J.; Shipps, G. W., Jr.; Zhao, L.; Siddiqui, M. A.; Popovici-Muller, J.; Duca, J. S.; Hruza, A. W.; Fischmann, T. O.; Madison, V. S.; Zhang, R.; McNemar, C. W.; Mayhood, T. W.; Windsor, W. T.; Lees, E. M.;  Parry, D. A. WO 2007/022241.

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